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WAY-100635 Maleate
CAS No. 1092679-51-0
WAY-100635 Maleate ( WAY 100635 | WAY-100635 | WAY100635 Maleate )
产品货号. M17140 CAS No. 1092679-51-0
WAY-100635 是一种特异性有效的 5-HT 受体拮抗剂 (IC50=0.95 nM)。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥308 | 有现货 |
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5MG | ¥494 | 有现货 |
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10MG | ¥778 | 有现货 |
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25MG | ¥1531 | 有现货 |
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50MG | ¥2843 | 有现货 |
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100MG | ¥4228 | 有现货 |
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500MG | ¥9477 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称WAY-100635 Maleate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述WAY-100635 是一种特异性有效的 5-HT 受体拮抗剂 (IC50=0.95 nM)。
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产品描述WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.
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体外实验The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors.WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) .
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体内实验WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal Model:Male Sprague-Dawley rats (220-240 g)Dosage:1 mg/kg Administration:Subcutaneous injection (Pharmacokinetic study)Result:Reduced total abstinence score, increased immobility time and the burying behavior was increased.
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同义词WAY 100635 | WAY-100635 | WAY100635 Maleate
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通路Others
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靶点Other Targets
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受体5-HT
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number1092679-51-0
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分子量538.64
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分子式C25H34N4O2·C4H4O4
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 250 mg/mL 464.13 mM H2O : 25 mg/mL46.41 mM
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SMILESO=C(O)/C=C\C(=O)O.COc4ccccc4N3CCN(CCN(c1ccccn1)C(=O)C2CCCCC2)CC3
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化学全称N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Corradetti R, et al. J Pharmacol Exp Ther. 1996, 278(2), 679-688.
产品手册
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