WAY-100635 Maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

WAY-100635 是一种特异性有效的 5-HT 受体拮抗剂 (IC50=0.95 nM)。

WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.

The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors.WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) .

WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal Model:Male Sprague-Dawley rats (220-240 g)Dosage:1 mg/kg Administration:Subcutaneous injection (Pharmacokinetic study)Result:Reduced total abstinence score, increased immobility time and the burying behavior was increased.

WAY 100635 | WAY-100635 | WAY100635 Maleate

Others

Other Targets

5-HT

Neurological Disease

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1092679-51-0

538.64

C25H34N4O2·C4H4O4

>98% (HPLC)

DMSO : ≥ 250 mg/mL 464.13 mM H2O : 25 mg/mL46.41 mM

O=C(O)/C=C\C(=O)O.COc4ccccc4N3CCN(CCN(c1ccccn1)C(=O)C2CCCCC2)CC3

N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate

(-20℃)

With Ice Pack

≥ 2 years