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WAY-100635 Maleate

CAS No. 1092679-51-0

WAY-100635 Maleate ( WAY 100635 | WAY-100635 | WAY100635 Maleate )

产品货号. M17140 CAS No. 1092679-51-0

WAY-100635 是一种特异性有效的 5-HT 受体拮抗剂 (IC50=0.95 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥308 有现货
5MG ¥494 有现货
10MG ¥778 有现货
25MG ¥1531 有现货
50MG ¥2843 有现货
100MG ¥4228 有现货
500MG ¥9477 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    WAY-100635 Maleate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    WAY-100635 是一种特异性有效的 5-HT 受体拮抗剂 (IC50=0.95 nM)。
  • 产品描述
    WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.
  • 体外实验
    The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors.WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) .
  • 体内实验
    WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal Model:Male Sprague-Dawley rats (220-240 g)Dosage:1 mg/kg Administration:Subcutaneous injection (Pharmacokinetic study)Result:Reduced total abstinence score, increased immobility time and the burying behavior was increased.
  • 同义词
    WAY 100635 | WAY-100635 | WAY100635 Maleate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    5-HT
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    1092679-51-0
  • 分子量
    538.64
  • 分子式
    C25H34N4O2·C4H4O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 250 mg/mL 464.13 mM H2O : 25 mg/mL46.41 mM
  • SMILES
    O=C(O)/C=C\C(=O)O.COc4ccccc4N3CCN(CCN(c1ccccn1)C(=O)C2CCCCC2)CC3
  • 化学全称
    N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Corradetti R, et al. J Pharmacol Exp Ther. 1996, 278(2), 679-688.
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